Jeong D U, Dimsdale J E
Department of Psychiatry, Seoul National University College of Medicine, Korea.
Am J Hypertens. 1990 Oct;3(10):749-53. doi: 10.1093/ajh/3.10.749.
The ambulatory blood pressure and heart rate of twelve healthy volunteers were monitored on two separate days in the participants' work environment. All subjects were studied in a double-blind crossover design while they consumed caffeinated or decaffeinated coffee. We examined them at rest, during a standardized mental arithmetic task, and for 6 h of ambulatory monitoring in their regular work setting (research facility and hospital). On days of drinking caffeinated coffee, both systolic and diastolic blood pressure were consistently elevated at all time points (P less than .0005). In response to the mental arithmetic task, the increase in systolic blood pressure over the resting value was particularly exaggerated on caffeinated coffee (P = .0003). For heart rate, there were no effects from caffeine. The study demonstrates that the blood pressure-elevating effects of caffeine, well-known from laboratory studies, are sufficiently robust to be evident in patients' uncontrolled work environments. It implies the importance of caffeine restriction for hypertensive patients. It also indicates the utility of ambulatory blood pressure techniques in studying the blood pressure effects of various nutritional factors taken ad lib in the real world.
在参与者的工作环境中，于两个不同的日子对12名健康志愿者的动态血压和心率进行了监测。所有受试者均采用双盲交叉设计进行研究，期间他们饮用含咖啡因或不含咖啡因的咖啡。我们在他们休息时、进行标准化心算任务期间以及在其正常工作环境（研究机构和医院）中进行6小时动态监测时对他们进行了检查。在饮用含咖啡因咖啡的日子里，收缩压和舒张压在所有时间点均持续升高（P小于0.0005）。对于心算任务，饮用含咖啡因咖啡时收缩压相对于静息值的升高尤为明显（P = 0.0003）。对于心率，咖啡因没有影响。该研究表明，实验室研究中已知的咖啡因升高血压的作用足够显著，在患者不受控制的工作环境中也很明显。这意味着限制高血压患者咖啡因摄入的重要性。它还表明了动态血压技术在研究现实世界中随意摄入的各种营养因素对血压影响方面的实用性。
