Mikami H, Ogihara T, Tabuchi Y
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Am J Hypertens. 1990 Aug;3(8 Pt 2):147S-151S. doi: 10.1093/ajh/3.8.147.
Epidemiological and experimental studies have suggested that dietary calcium deficiency may lead to the development of hypertension. This article reviews findings in human trials on calcium intervention with special reference to the responses of blood pressure and biochemical variables. Calcium supplementation consistently resulted in decreased blood pressure in a subset of hypertensive and normotensive subjects, but led to increased blood pressure in some hypertensive patients. The variable blood pressure responses to calcium supplementation could not be predicted on the basis of routine biochemical parameters and appeared to be due to differences in the backgrounds of the subjects and/or the design and size of the trials. It is concluded that further studies are required on the hypotensive effect of calcium supplementation.
流行病学和实验研究表明，膳食钙缺乏可能导致高血压的发生。本文回顾了人体钙干预试验的结果，特别提及了血压和生化指标的反应。补钙在一部分高血压和血压正常的受试者中持续导致血压下降，但在一些高血压患者中却导致血压升高。补钙后血压的不同反应无法根据常规生化参数预测，似乎是由于受试者背景以及试验设计和规模的差异所致。结论是，需要进一步研究补钙的降压效果。
