Department of Orthopedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Ultrasound Med Biol. 2012 Feb;38(2):238-46. doi: 10.1016/j.ultrasmedbio.2011.11.005.
We investigated the effect of local low-intensity pulsed ultrasound (LIPUS) on polyethylene debris induced periprosthetic osteolysis. The periprosthetic osteolysis model was made by injecting endotoxin-free pure polyethylene particles into the distal part of the femur canal and inserting a stainless steel plug into this femur. The effects of polyethylene and LIPUS were assessed histologically and by the shear strength test and periprosthetic bone mineral density (BMD) test. Sixteen rabbits received a stainless steel plug on one side and both polyethylene and a stainless steel plug on the other side. Three months later, the side that received polyethylene showed periprosthetic osteolysis. Subsequently, another 16 rabbits received polyethylene plus local LIPUS (200 mW/cm(2) for 20 min daily) on one side and polyethylene alone on the other side. Three months later, LIPUS effectively prevented the periprosthetic osteolysis caused by polyethylene in this rabbit model.
我们研究了局部低强度脉冲超声（LIPUS）对聚乙烯颗粒诱导的人工关节周围骨溶解的影响。通过将无内毒素的纯聚乙烯颗粒注入股骨管的远端并将不锈钢塞插入该股骨，建立了人工关节周围骨溶解模型。通过组织学评估、剪切强度测试和人工关节周围骨密度（BMD）测试评估聚乙烯和 LIPUS 的效果。16 只兔子一侧接受不锈钢塞，另一侧同时接受聚乙烯和不锈钢塞。3 个月后，接受聚乙烯的一侧出现人工关节周围骨溶解。随后，另外 16 只兔子一侧接受聚乙烯加局部 LIPUS（200 mW/cm²，每天 20 分钟），另一侧接受单纯聚乙烯。3 个月后，LIPUS 有效预防了该兔模型中聚乙烯引起的人工关节周围骨溶解。
