Basaga H S
Department of Science Education, Middle East Technical University, Ankara, Turkey.
Biochem Cell Biol. 1990 Jul-Aug;68(7-8):989-98. doi: 10.1139/o90-146.
Toxic free radicals can be produced by many reactions required for the maintenance of normal metabolism and the production of energy in the cell. The reactivity of both primary and secondary radicals with biomolecules and in whole tissue systems is of interest, not only because of their importance in radiobiology but also because of the role these species play in toxicity and various disorders. Oxidant stress is known to increase the production of free radicals. In the presence of metals, especially iron, these radicals are converted into more damaging species. Trace elements play an important role in many systems that have evolved to deal with free radicals. The dietary status of the cell can affect the preventative antioxidant constituents of the cell. The chain-breaking antioxidant status can clearly be influenced by the dietary content of substances such as vitamins E and C.
维持细胞正常新陈代谢和能量产生所需的许多反应都会产生有毒自由基。初级和次级自由基与生物分子以及整个组织系统的反应性备受关注，这不仅是因为它们在放射生物学中的重要性，还因为这些物质在毒性和各种疾病中所起的作用。已知氧化应激会增加自由基的产生。在金属尤其是铁的存在下，这些自由基会转化为更具破坏性的物质。微量元素在许多已进化以应对自由基的系统中起着重要作用。细胞的饮食状况会影响细胞的预防性抗氧化成分。诸如维生素E和C等物质的饮食含量显然会影响链断裂抗氧化状态。
