Lima Vanessa Batista de Sousa, Sampaio Fabiane de Araújo, Bezerra Daila Leite Chaves, Moita Neto José Machado, Marreiro Dilina do Nascimento
Department of Nutrition, Universidade Federal do Piauí, Teresina, PI, Brazil.
Arq Bras Endocrinol Metabol. 2011 Dec;55(9):701-7. doi: 10.1590/s0004-27302011000900006.
This study assessed the relationship between the parameters of glycemic control, and zinc concentrations in blood and superoxide dismutase enzyme activity in type 2 diabetes patients.
Seventy-three individuals, aged between 25 and 59 years, were divided into the experimental group (type 2 diabetes patients, n = 36) and control group (n = 37). Plasma and erythrocyte zinc concentrations, superoxide dismutase activity, and parameters of glycemic control were analyzed.
Mean plasma zinc concentration was 74.1 ± 10.7 µg/dL and 68.8 ± 9.6 µg/dL, erythrocyte zinc concentration was 48.1 ± 9.5 µg/gHb and 41.2 ± 8.0 µg/gHb, and superoxide dismutase activity was 2248.9 ± 300.0 U/gHb and 2059.6 ± 285.4 U/gHb, in the experimental group and the control group, respectively (p < 0.05).
Type 2 diabetes patients showed a positive response to oxidative stress due to adequate zinc concentration in blood and increased activity of superoxide dismutase, and the enzyme was influenced by serum insulin.
本研究评估了2型糖尿病患者血糖控制参数与血液中锌浓度及超氧化物歧化酶活性之间的关系。
73名年龄在25至59岁之间的个体被分为实验组（2型糖尿病患者，n = 36）和对照组（n = 37）。分析了血浆和红细胞锌浓度、超氧化物歧化酶活性以及血糖控制参数。
实验组和对照组的平均血浆锌浓度分别为74.1±10.7μg/dL和68.8±9.6μg/dL，红细胞锌浓度分别为48.1±9.5μg/gHb和41.2±8.0μg/gHb，超氧化物歧化酶活性分别为2248.9±300.0U/gHb和2059.6±285.4U/gHb（p < 0.05）。
2型糖尿病患者由于血液中锌浓度充足和超氧化物歧化酶活性增加，对氧化应激表现出阳性反应，且该酶受血清胰岛素影响。
