University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Health Aff (Millwood). 2012 Jan;31(1):76-83. doi: 10.1377/hlthaff.2011.1075.
Type 2 diabetes prevention studies have shown that the onset of the disease can be delayed or prevented, chiefly by weight loss. But the current efforts to establish community-based lifestyle modification programs will not be very effective in preventing diabetes, largely because most overweight or obese people cannot maintain weight loss over time. A complex environment is driving greater food consumption along with less energy expenditure, making maintenance of weight loss extremely difficult. To improve the likelihood of achieving populationwide success in reducing the obesity pandemic, we need a better understanding of the biological processes that underlie the balance between intake and expenditure of energy. In the meantime, once diabetes develops, we can greatly reduce the likelihood of serious complications through early detection and proper medical management.
2 型糖尿病预防研究表明，疾病的发生可以通过减肥来延迟或预防。但是，目前建立基于社区的生活方式改变计划的努力在预防糖尿病方面效果不大，主要是因为大多数超重或肥胖的人无法长期保持体重减轻。复杂的环境导致食物摄入量增加，而能量消耗减少，这使得体重维持变得极其困难。为了提高在减少肥胖流行方面取得全面成功的可能性，我们需要更好地了解能量摄入和消耗之间平衡的生物学过程。同时，一旦糖尿病发生，我们可以通过早期检测和适当的医疗管理来大大降低严重并发症的可能性。
