Nutrition Unit, Geneva University Hospital, Geneva, Switzerland.
Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):99-106. doi: 10.1097/MCO.0b013e32834feab4.
The review aims at elucidating the role of lipid peroxidation of polyunsaturated fatty acids (PUFAs) in colorectal cancer (CRC) risk and treatment.
CRC is one of the most overriding threats to public health. Despite a broad range of treatments, up to 50% of patients will inevitably develop incurable metastatic disease. Peroxidation of PUFAs contributes to augmentation of oxidative stress and causes in consequence inflammation, which is one of the possible carcinogenic factors of CRC. End products of PUFAs might be used as biomarkers for CRC detection and surveillance for treatment. They also have cytotoxic effect in CRC cells. Experimental results suggest that ω-3 PUFAs could increase the efficacy of radiotherapy and chemotherapy of CRC.
Lipid peroxidation, one factor of oxidative stress, might play a paramount role not only in carcinogenesis but also in potential therapeutic strategy on CRC. End products of lipid peroxidation, such as malondialdehyde, 4-hydroxy-2-nonenal, and isoprostanes, could be used as biomarkers for cancer detection, surveillance of treatment outcome and prognostic index for CRC patients. Furthermore, malondialdehyde and 4-hydroxy-2-nonenal have cytotoxic effect not only in normal cells but also in CRC cancer cells, which implies the potential role of PUFAs in CRC treatment.
本文旨在阐明多不饱和脂肪酸（PUFAs）脂质过氧化在结直肠癌（CRC）风险和治疗中的作用。
CRC 是对公众健康最严重的威胁之一。尽管有广泛的治疗方法，但多达 50%的患者最终不可避免地会发展为无法治愈的转移性疾病。PUFAs 的过氧化作用会导致氧化应激的增加，并导致炎症，这是 CRC 的可能致癌因素之一。PUFAs 的终产物可作为 CRC 检测和治疗监测的生物标志物。它们对 CRC 细胞也具有细胞毒性作用。实验结果表明，ω-3 PUFAs 可以提高 CRC 放化疗的疗效。
脂质过氧化作为氧化应激的一个因素，不仅可能在致癌作用中发挥重要作用，而且可能在 CRC 的潜在治疗策略中发挥重要作用。脂质过氧化的终产物，如丙二醛、4-羟基-2-壬烯醛和异前列腺素，可作为癌症检测、治疗效果监测和 CRC 患者预后指数的生物标志物。此外，丙二醛和 4-羟基-2-壬烯醛不仅对正常细胞，而且对 CRC 癌细胞都有细胞毒性作用，这意味着 PUFAs 在 CRC 治疗中具有潜在作用。
