口腔高分化脂肪肉瘤/非典型脂肪瘤性肿瘤：三例报告并文献复习
Well-differentiated liposarcoma/atypical lipomatous tumor of the oral cavity: report of three cases and review of the literature.
作者信息
Piperi Evangelia, Tosios Konstantinos I, Nikitakis Nikolaos G, Kyriakopoulos Vasileios F, Tzerbos Fotios, Koutlas Ioannis G, Sklavounou Alexandra
机构信息
Department of Oral Pathology and Medicine, Dental School, University of Athens, 2 Thivon Street, 11527, Athens, Greece.
出版信息
Head Neck Pathol. 2012 Sep;6(3):354-63. doi: 10.1007/s12105-011-0327-2. Epub 2012 Jan 11.
Abstract
Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.
摘要
非典型脂肪瘤性肿瘤/高分化脂肪肉瘤（ALT/WDLS）是一种具有中等恶性行为的软组织肉瘤，最常累及腹膜后和下肢。口腔脂肪肉瘤是非常罕见的肿瘤，最常见的组织学亚型为ALT/WDLS。在本研究中，分别描述了另外3例ALT/WDLS病例，其中2例位于舌部，1例位于下唇。对先前英文文献中报道的63例口腔ALT/WDLS病例以及本研究中呈现的3例病例的显著临床病理特征进行分析表明，该肿瘤的惰性生物学行为证明将其归类为局部扩散的恶性肿瘤是合理的，从而采取较为保守的手术方法。
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