新型原创神经生长因子模拟物GK-2神经保护特性的体外研究
In vitro study of neuroprotective properties of GK-2, a new original nerve growth factor mimetic.
作者信息
Antipova T A, Gudasheva T A, Seredenin S B
机构信息
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2011 Mar;150(5):607-9. doi: 10.1007/s10517-011-1202-6.
New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate. GK-2 in a concentration of 10(-8)M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.
新型神经生长因子（NGF）模拟物GK-2，一种取代的二聚二肽，在浓度高达10^(-9)M时，在添加过氧化氢（H₂O₂）和谷氨酸后，对永生化小鼠海马神经元（HT-22系）培养物产生保护作用。浓度为10^(-8)M的GK-2可保护大鼠嗜铬细胞瘤PC-12细胞免受神经毒素MPTP的损伤。在原代培养的胚胎大鼠海马神经元中也观察到了该肽对氧化应激模型的神经保护作用。
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