Université Libre de Bruxelles, Chimie Organique et Photochimie, CP 160/08, av. F.D. Roosevelt, 1050 Bruxelles, Belgium.
Curr Top Med Chem. 2012;12(3):185-96. doi: 10.2174/156802612799079008.
Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for Ru(II) polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of Ru(II) polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing Ru(II) complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed.
自顺铂被发现以来，由于配位化学提供了众多可能性，基于其他金属的诊断或治疗剂的研究已经得到了广泛的扩展。本篇综述聚焦于新型钌（II）多氮杂芳烃配合物的研究进展，这些配合物具有作为细胞诊断的分子工具或未来生物医学应用中特定的细胞光试剂的应用潜力。报告了钌（II）多氮杂芳烃配合物与活细胞的相互作用，以及光氧化钌（II）配合物与核酸的光反应机制。还讨论了目前为提高其对 DNA 的反应活性和特异性而开发的新策略，特别是在基因沉默框架内。
