Friedrich-Alexander-University Erlangen-Nuremberg, Department of Chemistry and Pharmacy, Egerlandstrasse 1, 91058 Erlangen, Germany.
Curr Top Med Chem. 2012;12(3):197-209. doi: 10.2174/156802612799078946.
Transition metal complexes with oligopyridine ligands and ruthenium or rhenium centers have attracted a widespread interest with respect to biomedical applications as they are luminescent and form triplet excited states which may form (1)O(2). These complexes have been shown to enter living cells and even cellular nuclei. In addition detailed investigations of their interaction with proteins/enzymes have shown that they are capable of binding to these biomolecules, alter the redox state of the enzyme metal centre and induce different reactivity. The application of these complexes as photoactive metallodrugs will depend on their photophysical and photochemical properties. The potential of these complexes together with relevant aspects of their chemistry will be discussed in this review.
具有寡吡啶配体和钌或铼中心的过渡金属配合物因其在生物医学应用方面的发光性和三重激发态的形成（1）O（2）而受到广泛关注。这些配合物已被证明能够进入活细胞甚至细胞核。此外，对它们与蛋白质/酶相互作用的详细研究表明，它们能够与这些生物分子结合，改变酶金属中心的氧化还原状态，并诱导不同的反应性。这些配合物作为光活性金属药物的应用将取决于它们的光物理和光化学性质。本综述将讨论这些配合物的潜力及其化学的相关方面。
