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Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy.唾液中花生特异性 IgA 水平升高与花生舌下免疫治疗后的食物挑战结果相关。
J Allergy Clin Immunol. 2012 Apr;129(4):1159-62. doi: 10.1016/j.jaci.2011.11.045. Epub 2012 Jan 10.
2
Sublingual versus oral immunotherapy for peanut-allergic children: a retrospective comparison.舌下免疫疗法与口服免疫疗法治疗花生过敏儿童的回顾性比较
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3
Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial.舌下免疫治疗花生过敏：一项随机、双盲、安慰剂对照的多中心试验。
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4
Blocking antibodies induced by peanut oral and sublingual immunotherapy suppress basophil activation and are associated with sustained unresponsiveness.花生口服和舌下免疫治疗诱导的阻断抗体抑制嗜碱性粒细胞活化，并与持续无反应相关。
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5
Peanut allergen powder (Palforzia).花生过敏原粉末（Palforzia）。
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Current Trend in Immunotherapy for Peanut Allergy.花生过敏的免疫治疗新趋势
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8
Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens.花生口服免疫治疗可改变主要花生过敏原的 IgE 和 IgG4 反应。
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Modified peanut oral immunotherapy protocol safely and effectively induces desensitization.改良花生口服免疫疗法方案可安全有效地诱导脱敏。
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Epicutaneous immunotherapy for peanut allergy modifies IgG responses to major peanut allergens.花生过敏的经皮免疫疗法可改变对主要花生过敏原的IgG反应。
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Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons.抗IgE疗法与食物过敏的变应原特异性免疫疗法：权衡利弊
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All roads lead to IgA: Mapping the many pathways of IgA induction in the gut.条条大路通IgA：探寻肠道中IgA诱导的多种途径
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Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.唾液抗体谱与花生过敏反应的反应阈值和严重程度相关。
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Food Allergen Immunotherapy in the Treatment of Patients with IgE-Mediated Food Allergy.食物过敏原免疫治疗 IgE 介导的食物过敏患者的治疗。
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Targeting type 2 immunity and the future of food allergy treatment.靶向 2 型免疫与食物过敏治疗的未来。
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Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.食物特异性免疫球蛋白 A 与对花生或鸡蛋过敏原的天然耐受无关。
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How the Immune System Responds to Allergy Immunotherapy.免疫系统如何对过敏免疫疗法做出反应。
Biomedicines. 2022 Nov 5;10(11):2825. doi: 10.3390/biomedicines10112825.
10
Biomarkers in oral immunotherapy.口腔免疫治疗中的生物标志物。
J Zhejiang Univ Sci B. 2022;23(9):705-731. doi: 10.1631/jzus.B2200047.

本文引用的文献

1
Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization.舌下免疫疗法治疗花生过敏：脱敏的临床和免疫证据。
J Allergy Clin Immunol. 2011 Mar;127(3):640-6.e1. doi: 10.1016/j.jaci.2010.12.1083. Epub 2011 Feb 1.
2
Future therapies for food allergies.食物过敏的未来疗法。
J Allergy Clin Immunol. 2011 Mar;127(3):558-73; quiz 574-5. doi: 10.1016/j.jaci.2010.12.1098. Epub 2011 Jan 31.
3
One hundred years of allergen immunotherapy: time to ring the changes.过敏原免疫疗法百年：是时候做出改变了。
J Allergy Clin Immunol. 2011 Jan;127(1):3-7. doi: 10.1016/j.jaci.2010.11.032.
4
Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells.舌下草花粉免疫治疗与舌下调 Foxp3 表达细胞的增加以及过敏原特异性 IgG4、IgA 和血清抑制活性相关，该抑制活性可阻止 IgE 促进过敏原与 B 细胞结合。
Clin Exp Allergy. 2010 Apr;40(4):598-606. doi: 10.1111/j.1365-2222.2010.03462.x. Epub 2010 Feb 22.
5
Selective IgA deficiency in early life: association to infections and allergic diseases during childhood.早期生活中的选择性IgA缺乏：与儿童期感染及过敏性疾病的关联
Clin Immunol. 2009 Oct;133(1):78-85. doi: 10.1016/j.clim.2009.05.014. Epub 2009 Jun 21.
6
The immune geography of IgA induction and function.IgA诱导与功能的免疫地理学
Mucosal Immunol. 2008 Jan;1(1):11-22. doi: 10.1038/mi.2007.6.
7
Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based study.学龄前儿童过敏性疾病和哮喘与血清免疫球蛋白及唾液免疫球蛋白A的关系：一项基于社区的随访研究
Clin Exp Allergy. 2005 Jan;35(1):64-9. doi: 10.1111/j.1365-2222.2005.02141.x.
8
Soy immunotherapy for peanut-allergic mice: modulation of the peanut-allergic response.大豆免疫疗法对花生过敏小鼠的作用：调节花生过敏反应。
J Allergy Clin Immunol. 2004 Oct;114(4):915-21. doi: 10.1016/j.jaci.2004.06.049.
9
Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age.2岁以下婴儿唾液中总免疫球蛋白A和过敏原特异性免疫球蛋白A水平与过敏发展的关系。
Clin Exp Allergy. 2002 Sep;32(9):1293-8. doi: 10.1046/j.1365-2222.2002.01470.x.

唾液中花生特异性 IgA 水平升高与花生舌下免疫治疗后的食物挑战结果相关。

Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy.

出版信息

J Allergy Clin Immunol. 2012 Apr;129(4):1159-62. doi: 10.1016/j.jaci.2011.11.045. Epub 2012 Jan 10.

DOI:10.1016/j.jaci.2011.11.045
PMID:22236732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3763925/
Abstract

Peanut-specific IgA in saliva correlates with DBPCFC outcomes following peanut SLIT, suggesting that peanut-specific salivary IgA may be a potential biomarker for SLIT used to treat peanut allergy.

摘要

唾液中花生特异性 IgA 与花生 SLIT 后 DBPCFC 结果相关，提示花生特异性唾液 IgA 可能是用于治疗花生过敏的 SLIT 的潜在生物标志物。