Kuramoto Hiroyuki, Iwami Yoshiko, Sugimoto Naoko, Kato Chizuyo, Sugahara Takashi, Iida Manichi
Department of Cancer Detection for Females, Kanagawa Health Service Association, Yokohama, Japan.
Acta Cytol. 2012;56(1):74-9. doi: 10.1159/000332971. Epub 2012 Jan 4.
To evaluate the usefulness of a new liquid-based cytological procedure in a population screening program for cervix cancer.
Subjects were 1,000 women who underwent primary screening at the Kanagawa Health Service Association. The cytological specimens obtained by either cotton stick and Cytobrush® or Cervex-Brush® were processed using the Thinlayer Advanced Cytology Assay System (TACAS™), following the manufacturer's instructions.
(1) Cells were evenly distributed on specimens and stained evenly; (2) shrinkage of cells was 5% based on measurement of the nuclear diameters of granulocytes in comparison with those of the conventional procedure; (3) incidences of cells that occupied the whole area, 1/20≤, 1/4≤, 1/4> of the observation fields were 58.8, 26.2, 12.0 and 3.0%, respectively; (4) number of the squamous cells in cases with 1/4> was <5,000, in which specimen cells were correctly obtained from the squamocolumnar junction except in 3 cases (0.3%); (5) bleeding at cellular sampling was 5%, but did not disturb cell analysis; (6) inflammation caused by organisms was easily diagnosed; (7) detection rate of abnormal cytology was 4.3%, including ASC-US in 2.8% and ASC-H in 0.1%.
TACAS is a feasible and useful cytological procedure.
评估一种新的液基细胞学检查方法在宫颈癌群体筛查项目中的实用性。
对象为在神奈川保健服务协会接受初次筛查的1000名女性。通过棉棒和Cytobrush® 或Cervex-Brush® 获取的细胞学标本，按照制造商的说明，使用薄层高级细胞学检测系统（TACAS™）进行处理。
（1）细胞在标本上分布均匀且染色均匀；（2）与传统方法相比，根据粒细胞核直径测量，细胞收缩率为5%；（3）占据整个视野、1/20≤、1/4≤、1/4>视野的细胞发生率分别为58.8%、26.2%、12.0%和3.0%；（4）1/4>视野的病例中鳞状细胞数量<5000，其中除3例（0.3%）外，标本细胞均正确取自鳞柱交界；（5）细胞采样时出血率为5%，但不影响细胞分析；（6）由生物体引起的炎症易于诊断；（7）异常细胞学检测率为4.3%，包括非典型鳞状细胞不能明确意义（ASC-US）占2.8%和非典型鳞状细胞不排除高度病变（ASC-H）占0.1%。
TACAS是一种可行且有用的细胞学检查方法。
