Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, Canada.
J Hypertens. 2012 Feb;30(2):359-67. doi: 10.1097/HJH.0b013e32834f0b86.
Hypertension and obesity are major contributors to cardiovascular disease, and the relationship between these conditions is known to vary among ethnicities. However, this relationship has not previously been examined in aboriginal populations. The present investigation aimed to identify and compare this relationship among white (n = 3566), aboriginal (n = 850), East Asian (n = 446), and South Asian (n = 222) individuals from the province of British Columbia, Canada.
Blood pressure, BMI, and waist circumference were directly measured along with self-reported antihypertensive medication usage. Relative risk ratios were calculated to evaluate the risk of hypertension among individuals of varying BMI and waist circumference measurements. The relative risks of hypertension were compared both within and between four ethnic groups.
Greater relative risks for hypertension were observed among individuals with increased BMI or increased waist circumference among all four ethnic groups. Aboriginal individuals appear to experience the greatest increases in relative risk for hypertension with increased BMI or waist circumference compared to other ethnic groups. The differences in the risk of developing hypertension between aboriginal and white populations appear to be largely associated with differences in body composition (i.e., BMI or waist circumference). East Asian and South Asian populations experience greater relative risk for hypertension than white populations at the same level of BMI or waist circumference.
Hypertension prevention and treatment strategies among aboriginal, East Asian, and South Asian populations should target reducing fat mass and abdominal fat.
高血压和肥胖是心血管疾病的主要诱因,这些疾病在不同种族中的关系是已知的。然而,以前并没有在原住民群体中研究过这种关系。本研究旨在确定并比较加拿大不列颠哥伦比亚省的白种人(n=3566)、原住民(n=850)、东亚人(n=446)和南亚人(n=222)之间的这种关系。
直接测量血压、BMI 和腰围,并报告使用抗高血压药物的情况。计算相对风险比,以评估不同 BMI 和腰围测量值的个体患高血压的风险。在四个族裔群体内部和之间比较了高血压的相对风险。
在所有四个族裔群体中,BMI 或腰围增加的个体患高血压的相对风险增加。与其他族裔群体相比,原住民个体的 BMI 或腰围增加时,高血压的相对风险增加幅度似乎最大。原住民和白人群体之间发生高血压的风险差异似乎主要与身体成分(即 BMI 或腰围)的差异有关。东亚和南亚人群在相同的 BMI 或腰围水平下,患高血压的相对风险高于白人群体。
针对原住民、东亚和南亚人群的高血压预防和治疗策略应针对减少脂肪量和腹部脂肪。