Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland.
Int J Vitam Nutr Res. 2011 Jul;81(4):264-72. doi: 10.1024/0300-9831/a000072.
Increasing data suggest that higher 25-hydroxyvitamin D [25(OH)D] serum concentrations are advantageous for health. At present, strong evidence for causality is available for fracture and fall prevention, while promising epidemiologic and mechanistic studies suggest a key role of vitamin D in the preservation of cardiovascular health, and the prevention of cancer and other common chronic disease. For lower extremity function, fall prevention, hip bone density, and for fracture prevention optimal benefits are observed with 25(OH)D levels of at least 75 nmol/L to 100 nmol/L [1]. This threshold may be reached in 50 % of adults with 800 to 1000 IU vitamin D per day. This manuscript will discuss the evidence of vitamin D in fall and fracture prevention and how these data transfer to the most recent recommendations by the IOF (International Osteoporosis Foundation) and the IOM (Institute of Medicine).
越来越多的证据表明，较高的 25-羟维生素 D [25(OH)D]血清浓度对健康有益。目前，有强有力的证据表明其可预防骨折和跌倒，而有前景的流行病学和机制研究表明，维生素 D 在维持心血管健康和预防癌症和其他常见慢性疾病方面发挥着关键作用。对于下肢功能、跌倒预防、髋骨密度和骨折预防，最佳的 25(OH)D 水平为至少 75 nmol/L 至 100 nmol/L[1]。每天摄入 800 至 1000 IU 维生素 D，有 50%的成年人可以达到这一阈值。本文将讨论维生素 D 在预防跌倒和骨折方面的证据，以及这些数据如何转化为 IOF（国际骨质疏松基金会）和 IOM（医学研究所）的最新建议。
