Centre on Aging and Mobility, University of Zurich and Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Switzerland.
Dermatol Ther. 2010 Jan-Feb;23(1):23-30. doi: 10.1111/j.1529-8019.2009.01288.x.
Increasing data suggest that many or most adults in the United States and Europe would benefit from vitamin D supplements. This review summarizes the benefits of vitamin D with the strongest evidence today from randomized controlled trials for fall and fracture prevention. Beyond fall and fracture prevention, vitamin D may also reduce overall morbidity by multiple mechanisms. Prospective epidemiological studies supported by strong mechanistic evidence suggest a reduction of cardiovascular disease (incident hypertension and cardiovascular mortality) and colorectal cancer, extending to weaker evidence on immune-modulatory and anti-inflammatory benefits of vitamin D.
越来越多的数据表明，美国和欧洲的许多或大多数成年人都将从维生素 D 补充剂中受益。本综述总结了维生素 D 的益处，其中今天最强有力的证据来自随机对照试验，用于预防跌倒和骨折。除了预防跌倒和骨折外，维生素 D 还可能通过多种机制降低整体发病率。有强有力的机制证据支持的前瞻性流行病学研究表明，维生素 D 可降低心血管疾病（新发高血压和心血管死亡率）和结直肠癌的风险，并且有较弱的证据表明维生素 D 具有免疫调节和抗炎作用。
