欧洲裔和非裔女性 2 型糖尿病和乳腺癌风险的遗传易感性。
Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.
机构信息
Department of Health Studies,University of Chicago, Chicago, Illinois 60637, USA.
出版信息
Cancer Epidemiol Biomarkers Prev. 2012 Mar;21(3):552-6. doi: 10.1158/1055-9965.EPI-11-0979. Epub 2012 Jan 11.
BACKGROUND
Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight.
METHODS
We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.
RESULTS
We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk.
CONCLUSION
The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist.
IMPACT
The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk.
背景
流行病学研究报告称，2 型糖尿病（T2D）与乳腺癌风险之间存在正相关，与体重无关。
方法
我们研究了与非洲裔或欧洲裔 7 项研究中 2651 例乳腺癌病例和 2520 例对照相关的 40 种已知与 T2D 相关的遗传变异与乳腺癌风险之间的关系。
结果
我们发现，高加索女性中的两种 T2D 风险等位基因（rs5945326-G、rs12518099-C）和非洲裔女性中的一种 T2D 风险等位基因（rs7578597-T）与乳腺癌风险呈正相关，在名义显著性水平为 0.05，而两种 T2D 风险等位基因与高加索女性的乳腺癌风险呈负相关（rs1111875-C、rs10923931-T）。复合 T2D 易感性评分（风险等位基因数）与乳腺癌风险无显著相关性。
结论
在非洲裔或欧洲裔女性中，已确定的 T2D 遗传易感性变异与乳腺癌风险之间的关联如果存在的话，也可能很微弱。
影响
已知 T2D 风险等位基因的多效性效应不能解释 T2D 与乳腺癌风险之间的关联。
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