Centre 'Bioengineering,' Russian Academy of Sciences, Moscow, Russia.
FEMS Microbiol Lett. 2012 Apr;329(1):9-17. doi: 10.1111/j.1574-6968.2012.02497.x. Epub 2012 Feb 8.
We determined the complete mitochondrial genome sequence of the compactin-producing fungus Penicillium solitum strain 20-01. The 28 601-base pair circular-mapping DNA molecule encodes a characteristic set of mitochondrial proteins and RNA genes and is intron-free. All 46 protein- and RNA-encoding genes are located on one strand and apparently transcribed in one direction. Comparative analysis of this mtDNA and previously sequenced but unannotated mitochondrial genomes of several medically and industrially important species of the Aspergillus/Penicillium group revealed their extensive similarity in terms of size, gene content and sequence, which is also reflected in the almost perfect conservation of mitochondrial gene order in Penicillium and Aspergillus. Phylogenetic analysis based on concatenated mitochondrial protein sequences confirmed the monophyletic origin of Eurotiomycetes.
我们测定了产康普汀的青霉（Penicillium solitum）菌株 20-01 的完整线粒体基因组序列。这个 28601 碱基对的环状 DNA 分子编码了一组特征性的线粒体蛋白和 RNA 基因，并且不含内含子。所有 46 个蛋白编码基因和 RNA 编码基因都位于一条链上，显然是按照一个方向转录的。对该 mtDNA 与之前测序但未注释的几种具有医学和工业重要性的曲霉/青霉属物种的线粒体基因组进行比较分析表明，它们在大小、基因组成和序列方面具有广泛的相似性，这也反映在青霉属和曲霉属的线粒体基因排列几乎完全保守。基于串联线粒体蛋白序列的系统发育分析证实了散囊菌目的单系起源。
