Immunochemistry Laboratory, National Institute of Immunology, New Delhi, India.
Crit Rev Microbiol. 2012 May;38(2):168-81. doi: 10.3109/1040841X.2011.645519. Epub 2012 Jan 13.
Eosinophils have been associated with the pathophysiology of various allergic diseases and asthma. Eosinophils secrete a number of granule proteins that have been identified as effector molecules responsible for many of the actions of eosinophils. The four major eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and eosinophil peroxidase have been shown to be involved in a number of eosinophil associated functions. EDN possesses antiviral activity against single stranded RNA viruses like respiratory syncytial virus, Hepatitis and HIV, whereas ECP and MBP have antibacterial and antiparasitic properties. This review summarizes the studies on antipathogenic activities of eosinophil granule proteins against bacteria, viruses, protozoans and helminths.
嗜酸性粒细胞与各种过敏性疾病和哮喘的病理生理学有关。嗜酸性粒细胞分泌许多颗粒蛋白，这些蛋白已被确定为效应分子，负责嗜酸性粒细胞的许多作用。四种主要的嗜酸性粒细胞颗粒蛋白，主要碱性蛋白（MBP）、嗜酸性粒细胞阳离子蛋白（ECP）、嗜酸性粒细胞衍生的神经毒素（EDN）和嗜酸性粒细胞过氧化物酶，已被证明参与了许多与嗜酸性粒细胞相关的功能。EDN 对单链 RNA 病毒如呼吸道合胞病毒、肝炎和 HIV 具有抗病毒活性，而 ECP 和 MBP 具有抗细菌和抗寄生虫的特性。这篇综述总结了嗜酸性粒细胞颗粒蛋白对细菌、病毒、原生动物和寄生虫的抗病原体活性的研究。
