地西泮增强嘌呤能对中枢神经元的抑制作用。
Diazepam potentiation of purinergic depression of central neurons.
作者信息
Phillis J W
出版信息
Can J Physiol Pharmacol. 1979 Apr;57(4):432-5. doi: 10.1139/y79-066.
DOI:10.1139/y79-066
PMID:222411
Abstract
Intravenously or iontophoretically applied diazepam potentiated the depressant action of iontophoretically applied 5'-AMP on the spontaneous firing of rat cerebral cortical neurons. This potentiation of purinergic depression may be a result of the previously reported inhibition by diazepam of uptake of adenosine into brain tissues.
摘要
静脉注射或离子电渗法应用地西泮可增强离子电渗法应用5'-AMP对大鼠大脑皮质神经元自发放电的抑制作用。嘌呤能抑制作用的这种增强可能是先前报道的地西泮抑制腺苷摄取进入脑组织的结果。
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