Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey.
Acta Odontol Scand. 2013 Jan;71(1):38-44. doi: 10.3109/00016357.2011.650195. Epub 2012 Jan 16.
The aim of this study was to test the hypothesis that the systemic administration of extract of Ginkgo biloba (EGb) would prevent excessive tissue destruction in ligature-induced periodontitis in a rat model.
Thirty-two male Wistar albino rats were used in the current study. The rats were randomly divided into four groups of eight rats each: (1) non-ligated treatment (NL) group, (2) ligature-only (LO) group, (3) ligature plus GB28 (28 mg/kg, daily for 11 days) group and (4) ligature plus GB56 (56 mg/kg, daily for 11 days) group.
Measurement of alveolar bone loss in the mandibular molar tooth revealed significantly lower bone loss values in the LO group compared to groups NL, GB28 and GB56 (p < 0.05).
The present results are the first data which suggests that host response in periodontitis can be modified by EGb administration. EGb minimized progression of periodontal disease.
本研究旨在验证银杏叶提取物（EGb）全身给药是否能预防结扎诱导的牙周炎大鼠模型中过度的组织破坏。
本研究使用了 32 只雄性 Wistar 白化大鼠。这些大鼠被随机分为四组，每组 8 只：（1）非结扎治疗（NL）组，（2）结扎组（LO），（3）结扎加 GB28（28mg/kg，每日 11 天）组和（4）结扎加 GB56（56mg/kg，每日 11 天）组。
下颌磨牙牙槽骨丧失的测量显示，LO 组的骨丧失值明显低于 NL、GB28 和 GB56 组（p<0.05）。
本研究结果首次表明，EGb 给药可调节牙周炎中的宿主反应。EGb 最小化了牙周病的进展。
