Department of Internal Medicine, Korea University Anam Hospital, Anam-dong, Seongbuk-gu, Seoul 136-705, Korea.
Pathol Int. 2012 Feb;62(2):144-8. doi: 10.1111/j.1440-1827.2011.02766.x. Epub 2011 Nov 30.
Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by fibroblastic tissues that occupy the lumina of alveoli and alveolar ducts or respiratory bronchioles. Although adequate doses and durations of glucocorticoids can improve its condition, COP is sometimes resistant to glucocorticoid therapy and is often lethal.Herein, a very rare case of 'bronchiolar COP' that was confined to the respiratory bronchioles is reported. This case indicates that macrolides may act as anti-inflammatory agents in patients with COP. Timely and precise pathological diagnosis may corroborate clinician diagnoses and eventually improve chances to overcome the disease.
特发性机化性肺炎（COP）是一种特发性间质性肺炎，其特征是成纤维细胞组织占据肺泡和细支气管或呼吸性细支气管的管腔。尽管给予足够剂量和时间的糖皮质激素可以改善其病情，但 COP 有时对糖皮质激素治疗有抵抗作用，并且常常是致命的。本文报道了一例非常罕见的局限于呼吸性细支气管的“细支气管 COP”病例。该病例表明，大环内酯类药物可能在 COP 患者中发挥抗炎作用。及时和准确的病理诊断可以佐证临床医生的诊断，最终提高战胜疾病的机会。
