Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, FAMERP, SP, Brazil.
Acta Histochem. 2012 Oct;114(6):571-6. doi: 10.1016/j.acthis.2011.10.007. Epub 2012 Jan 11.
The use of prognostic markers for breast cancer is important for routine diagnosis and research. Interleukin-8 is a chemotactic cytokine produced by several cell types in response to inflammation, however, its expression, regulation and function are poorly understood. Recent studies have associated angiogenesis and inflammatory processes with tumor malignancy. The present study investigated the correlation between interleukin-8 expression and breast cancer prognosis. Interleukin-8 expression was assessed in 72 women with mammary neoplasia by immunohistochemistry and the results were statistically correlated with clinical-pathological findings. There was an inverse correlation between interleukin-8 expression and metastasis (p=0.03) and/or local recurrence (p=0.02). In the patient group that received post-surgery chemotherapy and radiotherapy, a lower interleukin-8 expression was found in those women that showed local recurrence (p=0.01). Multivariate logistic regression showed estrogen receptor negativity, progesterone positivity and metastasis with increased risk of death (p<0.05). The data reflect the complexity of the role of interleukin-8 in tumor microenvironment and support its classification as a possible prognostic marker, although more studies are necessary for its inclusion in clinical practice.
癌症预后标志物的应用对乳腺癌的常规诊断和研究非常重要。白细胞介素-8 是一种趋化细胞因子，可由多种细胞类型在炎症反应中产生，但它的表达、调控和功能尚不清楚。最近的研究表明，血管生成和炎症过程与肿瘤恶性程度有关。本研究调查了白细胞介素-8 表达与乳腺癌预后的相关性。通过免疫组织化学方法评估了 72 名患有乳腺肿瘤的女性的白细胞介素-8 表达情况，并将结果与临床病理发现进行了统计学相关性分析。白细胞介素-8 的表达与转移（p=0.03）和/或局部复发（p=0.02）呈负相关。在接受术后化疗和放疗的患者组中，局部复发的女性白细胞介素-8 表达水平较低（p=0.01）。多变量逻辑回归显示，雌激素受体阴性、孕激素阳性和转移增加了死亡的风险（p<0.05）。这些数据反映了白细胞介素-8 在肿瘤微环境中的作用的复杂性，并支持将其归类为可能的预后标志物，尽管还需要更多的研究来将其纳入临床实践。
