Washington University School of Medicine, Anatomy & Neurobiology, 660 S Euclid Avenue, St Louis, MO 63110, USA.
Neuroimage. 2012 Aug 15;62(2):1299-310. doi: 10.1016/j.neuroimage.2012.01.032. Epub 2012 Jan 10.
The opportunity to explore the human connectome using cutting-edge neuroimaging methods has elicited widespread interest. How far will the field be able to progress in deciphering long-distance connectivity patterns and in relating differences in connectivity to phenotypic characteristics in health and disease? We discuss the daunting nature of this challenge in relation to specific complexities of brain circuitry and known limitations of in vivo imaging methods. We also discuss the excellent prospects for continuing improvements in data acquisition and analysis. Accordingly, we are optimistic that major insights will emerge from human connectomics in the coming decade.
利用前沿的神经影像学方法探索人类连接组学已经引起了广泛的兴趣。在解析远距离连接模式以及将连接差异与健康和疾病中的表型特征联系起来方面，该领域将能取得多大的进展？我们讨论了这一挑战的艰巨性，以及与大脑电路特定复杂性和体内成像方法已知局限性相关的具体问题。我们还讨论了在数据采集和分析方面持续改进的极好前景。因此，我们乐观地认为，在未来十年中，人类连接组学将带来重大的见解。
