人类连接组计划：数据获取视角。
The Human Connectome Project: a data acquisition perspective.
机构信息
Department of Anatomy & Neurobiology, Washington University, St. Louis, MO, USA.
出版信息
Neuroimage. 2012 Oct 1;62(4):2222-31. doi: 10.1016/j.neuroimage.2012.02.018. Epub 2012 Feb 17.
Abstract
The Human Connectome Project (HCP) is an ambitious 5-year effort to characterize brain connectivity and function and their variability in healthy adults. This review summarizes the data acquisition plans being implemented by a consortium of HCP investigators who will study a population of 1200 subjects (twins and their non-twin siblings) using multiple imaging modalities along with extensive behavioral and genetic data. The imaging modalities will include diffusion imaging (dMRI), resting-state fMRI (R-fMRI), task-evoked fMRI (T-fMRI), T1- and T2-weighted MRI for structural and myelin mapping, plus combined magnetoencephalography and electroencephalography (MEG/EEG). Given the importance of obtaining the best possible data quality, we discuss the efforts underway during the first two years of the grant (Phase I) to refine and optimize many aspects of HCP data acquisition, including a new 7T scanner, a customized 3T scanner, and improved MR pulse sequences.
摘要
人类连接组计划（HCP）是一项为期 5 年的计划，旨在描述健康成年人的大脑连接和功能及其可变性。本综述总结了 HCP 研究人员联盟正在实施的数据采集计划，该联盟将使用多种成像方式以及广泛的行为和遗传数据研究 1200 名受试者（双胞胎及其非双胞胎兄弟姐妹）。成像方式将包括弥散张量成像（dMRI）、静息态 fMRI（R-fMRI）、任务诱发 fMRI（T-fMRI）、用于结构和髓鞘映射的 T1 和 T2 加权 MRI，以及磁共振脑磁图和脑电图（MEG/EEG）的组合。鉴于获得最佳数据质量的重要性，我们讨论了在赠款的头两年（第一阶段）期间正在进行的努力，以改进和优化 HCP 数据采集的许多方面，包括新的 7T 扫描仪、定制的 3T 扫描仪和改进的磁共振脉冲序列。
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