Hampson L G, Shennib H, Lough J O, Fried G M
Department of Surgery, Montreal General Hospital, McGill University, PQ.
Can J Surg. 1990 Oct;33(5):349-52.
Of 199 patients with gastric cancer seen at The Montreal General Hospital between 1970 and 1981, 104 were considered to have had a curative resection, and 26 of these were early gastric cancers (EGC). The authors compared early gastric cancers with advanced, but resectable, gastric cancers to determine whether EGC is a distinct entity or a stage in the progressive evolution of gastric cancer. They found that depth of invasion was the primary determinant of outcome, but that there was no discrete cut-off point between the depth of invasion associated with early and with advanced gastric cancers. The pathological features normally associated with a favourable prognosis in gastric cancer, such as absence of lymph-node metastases, an expanding growth pattern, intestinal metaplasia, and well-differentiated histologic features correlated highly with depth of invasion but did not appear to change abruptly between EGC and advanced resectable lesions. The authors conclude that EGC is not a distinct pathological or clinical entity but a stage in the progressive growth of gastric cancer.
1970年至1981年间在蒙特利尔综合医院就诊的199例胃癌患者中，104例被认为接受了根治性切除，其中26例为早期胃癌（EGC）。作者将早期胃癌与进展期但可切除的胃癌进行比较，以确定早期胃癌是一种独特的实体还是胃癌渐进发展过程中的一个阶段。他们发现，浸润深度是预后的主要决定因素，但早期胃癌和进展期胃癌的浸润深度之间没有明确的界限。通常与胃癌良好预后相关的病理特征，如无淋巴结转移、膨胀性生长模式、肠化生和高分化组织学特征，与浸润深度高度相关，但在早期胃癌和进展期可切除病变之间似乎没有突然变化。作者得出结论，早期胃癌不是一个独特的病理或临床实体，而是胃癌渐进生长过程中的一个阶段。
