Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Curr Oncol Rep. 2012 Apr;14(2):166-74. doi: 10.1007/s11912-012-0220-5.
Salivary gland carcinomas are a heterogeneous group of tumors with different biologic behavior. Given the lack of large randomized studies, there is no standard treatment for advanced and/or metastatic salivary gland tumors, and systemic therapy is empirically based. Tumor-specific recurrent chromosomal translocations and fusion oncogenes in aggressive head and neck malignancies have diagnostic, therapeutic, and prognostic implications. Pathognomonic fusion transcripts have been identified in subsets of mucoepidermoid carcinoma and adenoid cystic carcinoma. These translocations target 1) transcription factors involved in growth factor signaling and cell cycle regulation, 2) transcriptional co-activators, and 3) tyrosine kinase receptors. Prioritizing studies with a translational component to advance the molecular understanding of these cancers and molecular-targeted therapy clinical trials is critical.
唾液腺癌是一组具有不同生物学行为的异质性肿瘤。鉴于缺乏大型随机研究，晚期和/或转移性唾液腺癌没有标准的治疗方法，系统治疗是经验性的。侵袭性头颈部恶性肿瘤中肿瘤特异性的复发性染色体易位和融合癌基因具有诊断、治疗和预后意义。在黏液表皮样癌和腺样囊性癌亚组中已经确定了特征性的融合转录本。这些易位靶向 1）参与生长因子信号和细胞周期调节的转录因子，2）转录共激活因子，和 3）酪氨酸激酶受体。优先进行具有转化成分的研究对于深入了解这些癌症和分子靶向治疗临床试验至关重要。
