Department of Microscopic Morphology/Histology, Angiogenesis Research Center, "Victor Babes" University of Medicine and Pharmacy, Sq. EftimieMurgu No. 2, 300041 Timisoara, Romania.
Department of Ear-Nose-Throat, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Medicina (Kaunas). 2023 Jun 13;59(6):1140. doi: 10.3390/medicina59061140.
Cystic adenoid carcinoma (ACC) is a rare malignant epithelial tumor arising from exocrine glands and accounts for only 1% of head and neck cancers. ACCs are common in the fifth and sixth decades of life, predominantly in women, and characterized by slow progression, local aggression, recurrence, and high metastasis. Subglottotracheal ACC is a rare tumor in the pediatric population, with only a few cases reported in the literature. We present a case of a 16-year-old female who was diagnosed with ACC in the subglottic and tracheal region. The patient presented with respiratory failure but without a history of dysphonia, dyspnea, stridor, or dysphagia. The diagnosis was confirmed by a biopsy, and subsequent imaging studies showed a large tumor involving the subglottic and tracheal region. The therapeutic management of this patient has been challenging due to the rarity of this tumor in the pediatric population and the potential long-term complications associated with tumor recurrence and psychological impact. This case highlights the diagnostic and therapeutic challenges in the management of subglottotracheal ACC in children and the importance of a multidisciplinary approach to optimize patient outcomes.
腺样囊性癌（ACC）是一种罕见的来源于外分泌腺的恶性上皮肿瘤，仅占头颈部癌症的 1%。ACC 常见于 50-60 岁，以女性多见，其特点为进展缓慢、局部侵袭、复发和高转移。声门下气管 ACC 是儿童中的罕见肿瘤，文献中仅报道了少数几例。我们报告了一例 16 岁女性患者，在声门下和气管区域被诊断为 ACC。该患者表现为呼吸衰竭，但无声音嘶哑、呼吸困难、喘鸣或吞咽困难病史。诊断通过活检得到证实，随后的影像学研究显示一个累及声门下和气管区域的大肿瘤。由于该肿瘤在儿童中罕见，且与肿瘤复发和心理影响相关的潜在长期并发症，该患者的治疗管理极具挑战性。该病例强调了儿童声门下气管 ACC 的诊断和治疗挑战，以及多学科方法优化患者结局的重要性。
