*Department of Pathology, University Health Network †Department of Pathobiology and Laboratory medicine, University of Toronto, ON, Canada.
Adv Anat Pathol. 2013 Nov;20(6):367-77. doi: 10.1097/PAP.0b013e3182a92cc3.
In recent years the discovery of translocations and the fusion oncogenes that they result in has changed the way diagnoses are made in the salivary gland. These genetic aberrations are recurrent and reproducible and at the very least serve as powerful diagnostic tools in salivary gland diagnosis and salivary gland classification. They also show promise as prognostic markers and hopefully as targets of therapy. Many of these fusions have been found in other tumor types that show little to no overlap with their salivary gland counterparts, but effectively they are specific within the salivary gland. In this review the 5 tumors currently known to harbor translocations will be discussed, namely pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma, mammary analog secretory carcinoma, and hyalinizing clear cell carcinoma. The discovery and implications of each fusion will be highlighted and how they have helped reshape the current classification of salivary gland tumors.
近年来，易位的发现及其导致的融合癌基因改变了唾液腺的诊断方式。这些遗传异常是反复出现且可重现的，至少在唾液腺诊断和唾液腺分类方面是强有力的诊断工具。它们也有望成为预后标志物，并希望成为治疗靶点。许多这些融合在其他肿瘤类型中也有发现，这些肿瘤与唾液腺肿瘤几乎没有重叠，但在唾液腺中它们是特异的。在这篇综述中，将讨论目前已知存在易位的 5 种肿瘤，即多形性腺瘤、黏液表皮样癌、腺样囊性癌、乳腺样分泌癌和透明细胞癌。将重点介绍每种融合的发现及其意义，以及它们如何帮助重塑目前的唾液腺肿瘤分类。
