Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province/School of Biological Science and Technology, Hubei University for Nationalities, Enshi, China.
Appl Biochem Biotechnol. 2012 Mar;166(5):1215-24. doi: 10.1007/s12010-011-9506-6. Epub 2012 Jan 14.
To investigate the effects of selenium on the main active components of Cordyceps militaris fruit bodies, selenium-enriched cultivation of C. militaris and the main active components of the fruit bodies were studied. Superoxide dismutase (SOD) activity and contents of cordycepin, cordycepic acid, and organic selenium of fruit bodies were sodium selenite concentration dependent; contents of adenosine and cordycep polysaccharides were significantly enhanced by adding sodium selenite in the substrates, but not proportional to sodium selenite concentrations. In the cultivation of wheat substrate added with 18.0 ppm sodium selenite, SOD activity and contents of cordycepin, cordycepic acid, adenosine, cordycep polysaccharides, and total amino acids were enhanced by 121/145%, 124/74%, 325/520%, 130/284%, 121/145%, and 157/554%, respectively, compared to NS (non-selenium-cultivated) fruit bodies and wild Cordyceps sinensis; organic selenium contents of fruit bodies reached 6.49 mg/100 g. So selenium-enriched cultivation may be a potential way to produce more valuable medicinal food as a substitute for wild C. sinensis.
为了研究硒对蛹虫草子实体主要活性成分的影响，进行了富硒蛹虫草栽培及其子实体主要活性成分的研究。超氧化物歧化酶（SOD）活性和蛹虫草素、虫草酸和有机硒的含量与亚硒酸钠浓度有关；在基质中添加亚硒酸钠可显著提高腺苷和虫草多糖的含量，但与亚硒酸钠浓度不成比例。在添加 18.0ppm 亚硒酸钠的小麦基质中栽培，SOD 活性和蛹虫草素、虫草酸、腺苷、虫草多糖和总氨基酸的含量分别比 NS（非硒栽培）子实体和野生冬虫夏草提高了 121/145%、124/74%、325/520%、130/284%、121/145%和 157/554%；子实体中的有机硒含量达到 6.49mg/100g。因此，富硒栽培可能是一种生产更有价值的药用食品的潜在方法，可以替代野生的冬虫夏草。
