Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Magn Reson Imaging. 2012 May;35(5):1026-37. doi: 10.1002/jmri.23581. Epub 2012 Jan 13.
Perfusion provides oxygen and nutrients to tissues and is closely tied to tissue function while disorders of perfusion are major sources of medical morbidity and mortality. It has been almost two decades since the use of arterial spin labeling (ASL) for noninvasive perfusion imaging was first reported. While initial ASL magnetic resonance imaging (MRI) studies focused primarily on technological development and validation, a number of robust ASL implementations have emerged, and ASL MRI is now also available commercially on several platforms. As a result, basic science and clinical applications of ASL MRI have begun to proliferate. Although ASL MRI can be carried out in any organ, most studies to date have focused on the brain. This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care.
灌注为组织提供氧气和营养物质，与组织功能密切相关，而灌注紊乱是导致医疗发病率和死亡率的主要原因之一。自首次报道动脉自旋标记（ASL）用于无创灌注成像以来，已经过去了将近二十年。虽然最初的 ASL 磁共振成像（MRI）研究主要集中在技术开发和验证上，但已经出现了许多强大的 ASL 实现方法，并且现在也有几个平台可以提供商业 ASL MRI。因此，ASL MRI 的基础科学和临床应用已经开始迅速发展。虽然 ASL MRI 可以在任何器官中进行，但迄今为止大多数研究都集中在大脑上。本综述涵盖了 ASL MRI 在大脑中的选定研究和临床应用，以说明其在神经科学研究和临床护理中的潜力。
