Derra Aleksandra, Bator Martyna, Menżyk Tomasz, Kukla Michał
Department of Gastroenterology and Hepatology, Medical University of Silesia in Katowice, Poland.
Clin Exp Hepatol. 2018 Jun;4(2):55-71. doi: 10.5114/ceh.2018.75955. Epub 2018 May 25.
Nonalcoholic fatty liver disease (NAFLD) is intrahepatic ectopic lipid deposition which is present despite a lack of other causes of secondary hepatic fat accumulation. It is the most common chronic liver disorder in the welldeveloped countries. NAFLD is a multidisciplinary disease that affects various systems and organs and is inextricably linked to simple obesity, metabolic syndrome, insulin resistance and overt diabetes mellitus type 2. The positive energy balance related to obesity leads to a variety of systemic changes including modified levels of insulin, insulin- like growth factor-1, adipokines, hepatokines and cytokines. It is strongly linked to carcinogenesis and new evidence proves that NAFLD is associated with higher risk of all-cause mortality and cancer-specific mortality among cancer survivors. This article focuses on the association between NAFLD and extrahepatic gastrointestinal tract cancers, aiming to shed light on the pathomechanism of changes leading to the development of tumors.
非酒精性脂肪性肝病（NAFLD）是一种肝内异位脂质沉积，即便不存在其他导致继发性肝脂肪堆积的原因也依然会出现。它是发达国家最常见的慢性肝脏疾病。NAFLD是一种多学科疾病，会影响多个系统和器官，并且与单纯性肥胖、代谢综合征、胰岛素抵抗及显性2型糖尿病有着千丝万缕的联系。与肥胖相关的正能量平衡会导致多种全身性变化，包括胰岛素、胰岛素样生长因子-1、脂肪因子、肝因子和细胞因子水平的改变。它与致癌作用密切相关，新证据表明，NAFLD与癌症幸存者全因死亡率和癌症特异性死亡率的较高风险相关。本文重点关注NAFLD与肝外胃肠道癌症之间的关联，旨在阐明导致肿瘤发生的变化的发病机制。
