Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Invest Ophthalmol Vis Sci. 2012 Feb 13;53(2):698-703. doi: 10.1167/iovs.11-8624.
To characterize total retinal blood flow in a group of healthy subjects.
Included in this study were 64 healthy volunteers. Retinal venous diameters were measured using a dynamic vessel analyzer. Retinal blood velocities were measured using bidirectional laser Doppler velocimetry. All vessels with a diameter of >60 μm entering the optic nerve head were measured. Total retinal blood flow was measured by summing up all data from the individually measured vessels. In a subgroup of 10 healthy subjects measurements were also taken from the arterioles, and results obtained for total retinal blood flow as measured both from retinal venules and from retinal arterioles were compared.
Total retinal blood flow was 44.0 ± 13.3 μL/min. Retinal blood flow was highest in the temporal inferior quadrant, followed by the temporal superior quadrant, the nasal inferior quadrant, and the nasal superior quadrant (P < 0.001 each). In all quadrants retinal blood velocities were linearly correlated to vessel diameters. Retinal blood flow as measured in retinal venules (42.1 ± 13.0 μL/min) and in retinal arterioles (43.3 ± 12.1 μL/min) was similar (P = 0.16).
The present study provides reference values for total retinal blood flow in 64 healthy subjects. The interindividual variability in retinal blood flow is high, making it unlikely that individual diagnostics can be based on measurements of retinal blood flow. Total retinal blood flow, however, may be important in risk stratification, which needs to be proven in future studies.
描述一组健康受试者的视网膜总血流量。
本研究纳入了 64 名健康志愿者。使用动态血管分析仪测量视网膜静脉直径。使用双向激光多普勒流速计测量视网膜血流速度。测量所有直径>60μm 进入视神经头的血管。通过汇总所有单独测量血管的数据来测量视网膜总血流量。在 10 名健康受试者的亚组中，也从动脉中进行了测量，并比较了从视网膜小静脉和视网膜小动脉测量的视网膜总血流量的结果。
视网膜总血流量为 44.0±13.3μL/min。视网膜血流在颞下象限最高，其次是颞上象限、鼻下象限和鼻上象限（P<0.001）。在所有象限中，视网膜血流速度与血管直径呈线性相关。从视网膜小静脉（42.1±13.0μL/min）和视网膜小动脉（43.3±12.1μL/min）测量的视网膜血流量相似（P=0.16）。
本研究为 64 名健康受试者的视网膜总血流量提供了参考值。视网膜血流量的个体间变异性很高，因此不太可能基于视网膜血流量的测量进行个体诊断。然而，视网膜总血流量在风险分层中可能很重要，这需要在未来的研究中证明。
