Kochkorov Asan, Gugleta Konstantin, Zawinka Claudia, Katamay Robert, Flammer Josef, Orgul Selim
University Eye Clinic, Basel, Switzerland.
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4026-33. doi: 10.1167/iovs.06-0177.
To test whether the regularity and short-term changes of retinal vessel diameter are related to the history of cold hands and feet and to nailfold circulatory response to cooling.
In 13 vasospastic and 13 nonvasospastic young healthy women (based on their history of cold extremities and nailfold capillaroscopy) 20- to 30-second recordings of the ocular fundus was obtained with a retinal vessel analyzer. The spatial regularity of arterioles and venules was analyzed by means of the coefficient of variation of vessel diameter and by exploratory Fourier analysis of spatial frequencies. Temporal variability was analyzed as excursion amplitude of the vessel diameter, as a correlation of means and standard deviations of vessel diameter within a defined time period, and by Fourier analysis of temporal diameter change in the heartbeat frequency range.
Mean diameters of selected segments of arterioles (129.9 +/- 15.3 and 124.4 +/- 24.4 microm) and venules (150.8 +/- 14.6 and 149.3 +/- 19.6 microm) were not different between the vasospastic and nonvasospastic groups, respectively. Spatial variability: The coefficient of variation in arterioles was 8.8% +/- 2.8% and 6.1% +/- 1.7%, in venules 3.8% +/- 1.4%, and 3.6% +/- 0.9% in the vasospastic and nonvasospastic groups, respectively (difference by ANOVA, P = 0.017). Fourier analysis revealed differences between arterioles in the two groups, with relative Fourier power spectrum amplitudes of spatial frequencies higher in vasospastic eyes (Mann-Whitney P = 0.029). Temporal variability: The excursion amplitudes of vessel diameters were comparable in the two groups. Individual coefficients of correlation of successive means and standard deviations of the vessel diameter were 0.11 +/- 0.23 and 0.09 +/- 0.23 in the nonvasospastic group, and 0.25 +/- 0.40 and 0.24 +/- 0.22 in the vasospastic group, in the arterioles and venules, respectively (ANOVA: vasospastic versus nonvasospastic; P = 0.038). Fourier analysis in the heartbeat frequency range revealed differences in relative power spectrum amplitudes of temporal frequencies between arterioles in the two groups (higher in the vasospastic group, Mann-Whitney P = 0.029).
Retinal arterioles in healthy vasospastic women show higher spatial irregularity and an increased vessel diameter variation within the temporal frequency of the heartbeat than do arterioles in nonvasospastic women.
测试视网膜血管直径的规律性和短期变化是否与手足冰凉病史以及甲襞循环对冷却的反应有关。
在13名血管痉挛性和13名非血管痉挛性年轻健康女性中（基于她们的四肢发冷病史和甲襞毛细血管镜检查结果），使用视网膜血管分析仪对眼底进行20至30秒的记录。通过血管直径的变异系数和空间频率的探索性傅里叶分析来分析小动脉和小静脉的空间规律性。通过血管直径的偏移幅度、在定义时间段内血管直径的均值和标准差的相关性以及心跳频率范围内血管直径变化的傅里叶分析来分析时间变异性。
血管痉挛组和非血管痉挛组中，所选小动脉段（分别为129.9±15.3和124.4±24.4微米）和小静脉段（分别为150.8±14.6和149.3±19.6微米）的平均直径无差异。空间变异性：血管痉挛组和非血管痉挛组中小动脉的变异系数分别为8.8%±2.8%和6.1%±1.7%，小静脉分别为3.8%±1.4%和3.6%±0.9%（方差分析差异，P = 0.017）。傅里叶分析显示两组小动脉之间存在差异，血管痉挛性眼睛中空间频率的相对傅里叶功率谱幅度更高（曼-惠特尼检验P = 0.029）。时间变异性：两组血管直径的偏移幅度相当。非血管痉挛组中小动脉和小静脉中，血管直径连续均值和标准差的个体相关系数分别为0.11±0.23和0.09±0.23，血管痉挛组分别为0.25±0.40和0.24±0.22（方差分析：血管痉挛组与非血管痉挛组；P = 0.038）。心跳频率范围内的傅里叶分析显示两组小动脉之间时间频率的相对功率谱幅度存在差异（血管痉挛组更高，曼-惠特尼检验P = 0.029）。
与非血管痉挛性女性相比，健康的血管痉挛性女性的视网膜小动脉表现出更高的空间不规则性，并且在心跳的时间频率内血管直径变化增加。
