University of Iceland, Reykjavik, Iceland.
Invest Ophthalmol Vis Sci. 2012 Aug 13;53(9):5433-42. doi: 10.1167/iovs.12-9912.
We measured oxygen saturation in retinal vessels of healthy eyes to determine the effects of age, sex, and cardiovascular parameters, as well as the reliability of the measurements and topographic differences.
The Oxymap T1 retinal oximeter is based on a fundus camera. It simultaneously captures retinal images at two different wavelengths and estimates retinal vessel oxygen saturation. Mean saturation of main retinal arterioles and venules was measured in 120 healthy individuals aged 18-80 years (median 47 years). Of the 120 participants 44 (37%) were male (49 years) and 76 (63%) female (44 years).
Oxygen saturation was 92.2 ± 3.7% (mean ± SD) in retinal arterioles and 55.6 ± 6.3% in venules. No significant difference in oxygen saturation was found between left and right eyes. The inferotemporal quadrant had lower oxygen saturation in arterioles and venules (P < 0.0001). Arteriolar oxygen saturation was stable with age. Venular oxygen saturation in males decreased by 1.9 ± 0.6% (mean ± SEM) per 10 years of age (P = 0.003) and by 0.7 ± 0.4% in females (P = 0.068). Arteriovenous (AV) difference increased by 1.5 ± 0.5% per 10 years in males (P = 0.004) and 1.0 ± 0.4% (P = 0.007) in females. For every 10 mm Hg increase in ocular perfusion pressure, oxygen saturation in arterioles increased by 0.9 ± 0.4% (P = 0.024) and in venules by 1.2 ± 0.7% (P = 0.075).
Retinal arteriolar oxygen saturation is stable in healthy individuals, while there is a significant decrease in venular oxygen saturation with age in males and a similar trend in females. AV difference increases significantly with age for both sexes. Our study provided normative data for spectrophotometric retinal oximetry in the Caucasian population.
我们测量了健康人眼视网膜血管中的氧饱和度，以确定年龄、性别和心血管参数的影响，以及测量的可靠性和局部差异。
Oxymap T1 视网膜血氧计基于眼底照相机。它同时在两个不同的波长捕获视网膜图像，并估计视网膜血管的氧饱和度。在 120 名年龄在 18-80 岁（中位数 47 岁）的健康个体中测量主要视网膜动脉和小静脉的平均饱和度。在 120 名参与者中，44 名（37%）为男性（49 岁），76 名（63%）为女性（44 岁）。
视网膜动脉中的氧饱和度为 92.2±3.7%（平均值±标准差），小静脉中的氧饱和度为 55.6±6.3%。左右眼之间的氧饱和度无显著差异。下颞象限的动脉和小静脉的氧饱和度较低（P<0.0001）。动脉氧饱和度随年龄稳定。男性静脉氧饱和度每 10 岁下降 1.9±0.6%（平均值±SEM）（P=0.003），女性下降 0.7±0.4%（P=0.068）。男性的动静脉（AV）差值每 10 岁增加 1.5±0.5%（P=0.004），女性增加 1.0±0.4%（P=0.007）。眼灌注压每增加 10mmHg，动脉中的氧饱和度增加 0.9±0.4%（P=0.024），静脉中的氧饱和度增加 1.2±0.7%（P=0.075）。
在健康个体中，视网膜动脉氧饱和度是稳定的，而男性的静脉氧饱和度随着年龄的增长而显著下降，女性也有类似的趋势。两性的 AV 差值随年龄显著增加。本研究为白种人群的分光光度视网膜血氧测定提供了正常参考值。
