BIOAIRlab, European Center of Thoracic Research (CERT), University Hospital Careggi, Florence, Italy.
Transpl Int. 2012 Apr;25(4):369-82. doi: 10.1111/j.1432-2277.2011.01426.x. Epub 2012 Jan 16.
Mesenchymal stromal cells (MSCs), a rare heterogeneous subset of pluripotent stromal cells that can be easily isolated from different adult tissues, in vitro expanded and differentiated into multiple lineages, are immune privileged and, more important, display immunomodulatory capacities. Because of this, they are the preferred cell source in tissue-engineered replacements, not only in autogeneic conditions, where they do not evoke any immune response, but especially in the setting of allogeneic organ and tissue replacements. However, more preclinical and clinical studies are requested to completely understand MSC's immune biology and possible clinical applications. We herein review the immunogenicity and immunomodulatory properties of MSCs, their possible mechanisms and potential clinical use for tissue-engineered organ and tissue replacement.
间充质基质细胞（MSCs）是一种罕见的多能基质细胞异质性亚群，可从不同的成人组织中轻易分离、体外扩增和分化为多种谱系，具有免疫特权，更重要的是具有免疫调节能力。正因为如此，它们是组织工程替代物的首选细胞来源，不仅在自体条件下不会引起任何免疫反应，而且特别适用于同种异体器官和组织替代物的情况。然而，为了完全了解 MSC 的免疫生物学和可能的临床应用，还需要更多的临床前和临床研究。本文综述了 MSCs 的免疫原性和免疫调节特性、其可能的机制以及在组织工程器官和组织替代中的潜在临床应用。
