Department of Medicine, Columbia University, New York, New York 10032, USA.
Annu Rev Med. 2012;63:317-28. doi: 10.1146/annurev-med-043010-144749.
Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling network that coordinates adaptive and apoptotic responses. There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress.
内质网（ER）正常功能的紊乱会触发一个信号网络，协调适应性和细胞凋亡反应。越来越多的证据表明，内质网应激与许多疾病的发生和发展有关，包括神经退行性疾病、动脉粥样硬化、2 型糖尿病、肝病和癌症。随着对潜在分子机制的深入了解，针对内质网应激反应的治疗干预可能是治疗由内质网应激引起的各种疾病的潜在策略。
