Zhuo J, Yang T, Zeng Y, Lu L
Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin.
Chin Med J (Engl). 1995 Dec;108(12):902-6.
We analyzed the data from seroepidemiologic survey of anti-HTLV-I serum antibody (HTLV-1 Ab) and 16 adult cases of T-cell leukemia (ATL) in China (1984-1994). The results showed that the positive rate of HTLV-I Ab of the population of China was 0.54%, the birth or residence places of HTLV-I carriers and all the patients with ATL were mainly distributed in the coastal provinces and the northeast China, and a small endemic area of HTLV-I and ATl was found in Fujian Province (HTLV-I Ab positive rate, 2.1%). The HTLV-I in China may be transmitted from Japan or originated from China. The clinical characteristics of the cases included onset in adulthood; frequent skin lesions, lymphadenopathy and hepatosplenomegaly; no mediastinal mass; the ATL cells from peripheral blood with polymorphism nuclei and mature T cell immunophenotype HTLV-IAb positive in most of the cases tested (5/8); mostly acute type; with a median survival period of 3.5 months.
我们分析了中国（1984 - 1994年）抗人嗜T淋巴细胞病毒I型血清抗体（HTLV - 1 Ab）血清流行病学调查数据以及16例成人T细胞白血病（ATL）病例。结果显示，中国人群中HTLV - 1 Ab阳性率为0.54%，HTLV - 1携带者和所有ATL患者的出生地或居住地主要分布在沿海省份和中国东北地区，在福建省发现了一个HTLV - 1和ATL的小流行区（HTLV - 1 Ab阳性率为2.1%）。中国的HTLV - 1可能从日本传播而来或起源于中国。病例的临床特征包括成年发病；频繁出现皮肤病变、淋巴结病和肝脾肿大；无纵隔肿块；外周血中的ATL细胞具有多形核和成熟T细胞免疫表型，大多数检测病例（5/8）中HTLV - 1 Ab呈阳性；大多为急性型；中位生存期为3.5个月。
