Department of Medicine, Faculty of Medicine, Umm AlQura University, Makkah, Saudi Arabia.
Saudi J Gastroenterol. 2012 Jan-Feb;18(1):23-5. doi: 10.4103/1319-3767.91733.
BACKGROUND/AIM: To identify the prevalence of gluten sensitivity in a healthy adult Saudi population within a low endemic area of celiac disease using IgA tissue transglutaminase antibody. The study was conducted as a prospective pilot study for Saudi attendees of a blood donation centre at King Faisal Specialist Hospital & Research Centre in Jeddah, Saudi Arabia.
Individuals were invited to participate in the study and screened for gluten sensitivity using immunoglobulin A tissue transglutaminase antibody (IgA TTG) along with serum IgA level. Descriptive data was presented and expressed as mean value; correlation between variables was estimated using Pearson correlation, and nonparametric data using Pearson rho correlation (level of P value <0.05 is considered to be statistically significant).
Two hundred and four individuals (122 males and 82 females, mean age 35 years) attending the blood donation centre were screened. Three individuals tested positive for IgA TTG showing normal IgA level (1 female and 2 males) with a 1.5% prevalence in the cohort.
Positive celiac screening is present at a low prevalence rate in our adult population, in which the individuals' age and their serum IgA levels are not associated with the positivity level. A study on a larger scale with the application of histologic confirmation of positive cases is needed.
背景/目的：使用 IgA 组织转谷氨酰胺酶抗体在患有乳糜泻的低流行地区的沙特健康成年人群中确定麸质敏感性的患病率。该研究是在沙特阿拉伯吉达的法伊萨尔国王专科医院和研究中心的献血中心的沙特参与者中进行的前瞻性试点研究。
邀请个人参加研究，并使用免疫球蛋白 A 组织转谷氨酰胺酶抗体 (IgA TTG) 以及血清 IgA 水平筛查麸质敏感性。呈现描述性数据，并表示为平均值；使用 Pearson 相关系数估计变量之间的相关性，使用 Pearson rho 相关系数（P 值<0.05 被认为具有统计学意义）估计非参数数据。
筛查了 204 名参加献血中心的个人（122 名男性和 82 名女性，平均年龄 35 岁）。有 3 名 IgA TTG 检测呈阳性的个体表现出正常的 IgA 水平（1 名女性和 2 名男性），队列中的患病率为 1.5%。
在我们的成年人群中，阳性乳糜泻筛查的患病率较低，其中个体的年龄和血清 IgA 水平与阳性水平无关。需要进行更大规模的研究，并对阳性病例进行组织学确认。
