Ghoshal Shivani, Gokhale Sankalp, Rebovich Gail, Caplan Louis R
Harvard Medical School, Boston, MA, USA.
Rev Neurol Dis. 2011;8(3-4):e55-67.
Delirium is sometimes defined as acute onset of either overactivity or underactivity. This article reviews the nature and clinico-anatomical locations of lesions in patients with reduced activity. The term abulia is used to describe global underactivity. Abulia is customarily explained by interruptions in frontal-subcortical circuitry. These interruptions can occur with lesions in the frontal lobes, caudate nuclei, midbrain, and thalamus. The article describes the anatomy of frontal and subcortical circuits and reviews in detail individual cases and series of patients with reduced initiative and activity who have had localized central nervous system lesions.
谵妄有时被定义为活动过度或活动不足的急性发作。本文回顾了活动减少患者病变的性质和临床解剖位置。“意志缺失”一词用于描述整体活动不足。意志缺失通常由额叶-皮质下回路中断来解释。这些中断可发生于额叶、尾状核、中脑和丘脑的病变。本文描述了额叶和皮质下回路的解剖结构，并详细回顾了患有局部中枢神经系统病变且主动性和活动减少的个体病例及系列患者。
