Kanta Jirí
Charles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biochemistry, Czech Republic.
Acta Medica (Hradec Kralove). 2011;54(3):97-101. doi: 10.14712/18059694.2016.28.
Wound healing is a complex physiological process important for tissue homeostasis. An acute injury initiates massive cell migration, proliferation and differentiation, synthesis of extracellular matrix components, scar formation and remodelling. Blood flow and tissue oxygenation are parts of the complex regulation of healing. Higher organisms utilize molecular oxygen as a terminal oxidant. This way of gaining energy for vital processes such as healing leads to the production of a number of oxygen compounds that may have a defensive or informatory role. They may be harmful when present in high concentrations. Both the lack and the excess of reactive oxygen species may influence healing negatively.
伤口愈合是一个对组织稳态很重要的复杂生理过程。急性损伤会引发大量细胞迁移、增殖和分化、细胞外基质成分的合成、瘢痕形成和重塑。血流和组织氧合是愈合复杂调节的一部分。高等生物利用分子氧作为终端氧化剂。这种为诸如愈合等重要过程获取能量的方式会导致产生一些可能具有防御或信息作用的含氧化合物。当它们以高浓度存在时可能是有害的。活性氧的缺乏和过量都可能对愈合产生负面影响。
