Morrison J E, Friesen R H
Department of Anesthesiology, Children's Hospital, Denver, Colorado 80218.
Can J Anaesth. 1990 Oct;37(7):801-3. doi: 10.1007/BF03006541.
A 20-month-old child received 25 brief halothane general anaesthetics over a five-week period to allow cranial irradiation treatments for a posterior fossa ependymoma. Personality change during the last week of the treatment protocol raised the question of possible bromide intoxication. Serum bromide concentrations, using a gold chloride assay technique, were monitored at that time, and at four- and six-week intervals thereafter. Serum bromide concentrations demonstrated a four-fold change during this period ranging from peak levels of 2.2 mEq.L-1 (176 micrograms.kg-1) during the fifth week of treatment decreasing to less than 0.5 mEq.L-1 (less than 40 micrograms.ml-1) six weeks following the end of treatments. This demonstrates the possibility for repetitive, short halothane exposures to result in elevations of serum bromide and the potential of bromide intoxication in paediatric neuro-oncology patients.
一名20个月大的儿童在五周内接受了25次短暂的氟烷全身麻醉，以便为后颅窝室管膜瘤进行颅脑放射治疗。治疗方案最后一周出现的性格变化引发了溴中毒可能性的问题。当时使用氯化金检测技术监测血清溴浓度，并在其后四周和六周的间隔时间进行监测。在此期间，血清溴浓度出现了四倍的变化，从治疗第五周的峰值水平2.2毫当量/升（176微克/千克）降至治疗结束六周后的低于0.5毫当量/升（低于40微克/毫升）。这表明小儿神经肿瘤患者反复、短期接触氟烷有可能导致血清溴升高及溴中毒。
