Pediatric TB Clinic, BJ Wadia Hospital for Children, Mumbai, India.
Indian Pediatr. 2011 Dec;48(12):977-9.
Emergence of resistance to two most potent first line anti-TB drugs i.e. isoniazid and rifampicin (multidrug resistant TB MDR TB) is well known, but, the second line drugs used to treat MDR-TB are also showing resistance to the same strain of Mycobacteria (extensively drug resistance TB, XDR-TB). We report 3 children with partial XDR TB. Two responded to treatment while one was lost to follow-up.
对两种最有效的一线抗结核药物(即异烟肼和利福平)产生耐药性(耐多药结核 MDR-TB)是众所周知的,但用于治疗 MDR-TB 的二线药物也对同一种分枝杆菌(广泛耐药结核,XDR-TB)产生了耐药性。我们报告了 3 例部分 XDR-TB 患儿。其中 2 例对治疗有反应,1 例失访。