Department of Food Science, Faculty of Agricultural Sciences, Aarhus University, Tjele, Denmark.
Nutrients. 2010 Nov;2(11):1141-55. doi: 10.3390/nu2111141. Epub 2010 Nov 23.
The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using (1)H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.
采用（1）H NMR 代谢组学方法研究了益生菌酸化乳产品对肠易激综合征（IBS）患者血清代谢物谱的影响，并与非益生菌酸化乳产品进行了比较。8 周内，IBS 患者每天饮用 0.4 升益生菌发酵乳或非益生菌酸化乳。两种饮食均导致血清 L-乳酸和 3-羟基丁酸水平升高。我们的结果表明，酸化乳的摄入具有相同的作用，而与益生菌的添加无关。以前在基于问卷调查的症状缓解评估中也得到了类似的结果。因此，益生菌的特定作用在患者主观症状评估和血清代谢物水平上均不存在。然而，在患者水平上，症状缓解与代谢物反应之间没有对应关系。
