Giovanni Galli Laboratory of Biochemistry and Molecular Biology of Lipids and Mass Spectrometry, Department of Pharmacological Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.
Nutrients. 2010 May;2(5):551-71. doi: 10.3390/nu2050551. Epub 2010 May 25.
Post-translational modifications of chromatin contribute to the epigenetic control of gene transcription. The response to food intake and individual nutrients also includes epigenetic events. Bile acids are necessary for lipid digestion and absorption, and more recently have emerged as signaling molecules. Their synthesis is transcriptionally regulated also in relation to the fasted-to-fed cycle, and interestingly, the underlying mechanisms include chromatin remodeling at promoters of key genes involved in their metabolism. Several compounds present in nutrients affect gene transcription through epigenetic mechanisms and recent studies demonstrate that, beyond the well known anti-cancer properties, they beneficially affect energy metabolism.
染色质的翻译后修饰有助于基因转录的表观遗传控制。对食物摄入和个别营养素的反应也包括表观遗传事件。胆汁酸是脂质消化和吸收所必需的，最近也被认为是信号分子。它们的合成也与禁食到进食周期有关，转录调控，有趣的是，潜在的机制包括涉及它们代谢的关键基因启动子处的染色质重塑。营养物质中的几种化合物通过表观遗传机制影响基因转录，最近的研究表明，除了众所周知的抗癌特性外，它们还有益地影响能量代谢。
