Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Melen Street, Cameroon.
Nutrients. 2011 Jul;3(7):712-24. doi: 10.3390/nu3070712. Epub 2011 Jul 18.
HIV-infected patients develop abnormalities of glucose metabolism due to the virus and antiretroviral drugs. Spirulina and soybean are nutritional supplements that are cheap, accessible in our community and affect glucose metabolism. We carried out a randomized study to assess the effect of Spirulina platensis versus soybean as a food supplement on HIV/HAART-associated insulin resistance (IR) in 33 insulin-resistant HIV-infected patients. The study lasted for two months at the National Obesity Centre of Cameroon. Insulin resistance was measured using the short insulin tolerance test. Physical activity and diet did not change over the study duration. On-treatment analysis was used to analyze data. The Mann-Whitney U test, the Students T test and the Chi square test were used as appropriate. Curve gradients were analyzed using ANCOVA. Seventeen subjects were randomized to spirulina and 16 to soybean. Each received 19 g of supplement daily. The follow up rate was 65% vs. 100% for spirulina and soybean groups, respectively, and both groups were comparable at baseline. After eight weeks, insulin sensitivity (IS) increased by 224.7% vs. 60% in the spirulina and soybean groups respectively (p < 0.001). One hundred per cent vs. 69% of subjects on spirulina versus soybean, respectively, improved their IS (p = 0.049) with a 1.45 (1.05-2.02) chance of improving insulin sensitivity on spirulina. This pilot study suggests that insulin sensitivity in HIV patients improves more when spirulina rather than soybean is used as a nutritional supplement.
ClinicalTrials.gov identifier NCT01141777.
由于病毒和抗逆转录病毒药物的影响，HIV 感染者会出现葡萄糖代谢异常。螺旋藻和大豆是营养补充剂，价格便宜，在我们的社区中容易获得，并且会影响葡萄糖代谢。我们进行了一项随机研究，以评估螺旋藻和大豆作为补充剂对 33 例 HIV/HAART 相关胰岛素抵抗（IR）的影响。这项研究在喀麦隆国家肥胖中心持续了两个月。胰岛素抵抗使用短胰岛素耐量试验进行测量。在研究期间，身体活动和饮食没有改变。采用治疗后分析来分析数据。适当使用 Mann-Whitney U 检验、学生 t 检验和卡方检验。使用协方差分析（ANCOVA）分析曲线梯度。17 名受试者被随机分配到螺旋藻组，16 名受试者被分配到大豆组。两组均每天接受 19 克补充剂。螺旋藻组和大豆组的随访率分别为 65%和 100%，两组基线时具有可比性。八周后，螺旋藻组和大豆组的胰岛素敏感性（IS）分别增加了 224.7%和 60%（p<0.001）。螺旋藻组和大豆组分别有 100%和 69%的受试者改善了 IS（p=0.049），使用螺旋藻改善胰岛素敏感性的可能性为 1.45（1.05-2.02）。这项初步研究表明，当螺旋藻而非大豆用作营养补充剂时，HIV 患者的胰岛素敏感性会得到更大改善。
ClinicalTrials.gov 标识符 NCT01141777。
