van Rijk-Zwikker G L, Mast F, Schipperheyn J J, Huysmans H A, Bruschke A V
Department of Cardiothoracic Surgery, Academic Hospital, Leiden, The Netherlands.
Circulation. 1990 Nov;82(5 Suppl):IV58-64.
Seven rigid (Carpentier) and six flexible (Duran) annuloplasty rings were implanted in healthy pigs. First, in the intact pig, cinefluoroscopy was used to record movements of the anulus. Results were compared with data from three pigs instrumented with a continuous radiopaque marker on the anulus. Pump function of all hearts with annuloplasty rings and function of the mitral valve were studied 4-6 weeks after the operation, first in the exposed heart and then subsequently in the isolated heart in a perfusion chamber at maximal filling pressure and normal or low arterial pressure. Separation of the blood-perfused coronary circulation from the crystalline solution pumped by the left heart allowed videoendoscopy of the working valve. Flexible rings interfered less with normal movements of the mitral anulus than rigid rings and caused less impairment of filling of the basal part of the ventricle, and the unloaded stroke volume was 16% larger. For normal arterial pressures, the differences were smaller and will be difficult to detect in clinical situations. A stiff anulus was seen to be pushed underneath the aortic valve during systole, which caused a mild subvalvular obstruction. The mean diastolic pressure gradient across rigid annuloplasty rings was slightly larger than across flexible rings of the same or slightly smaller diastolic size. Rigid rings change the pattern of movement of the leaflets; the mural leaflet remains immobile throughout diastole. Although Duran rings interfere less with valvular function and filling of the basal part of the ventricle than do Carpentier rings, the differences are small and probably only of limited clinical importance.
在健康猪体内植入了7个刚性(卡彭蒂埃)和6个柔性(杜兰)瓣环成形环。首先,在完整的猪身上,利用荧光透视法记录瓣环的运动。将结果与三只在瓣环上装有连续不透射线标记物的猪的数据进行比较。在术后4至6周,研究所有植入瓣环成形环的心脏的泵功能以及二尖瓣的功能,首先是在暴露的心脏中,然后是在灌注室中处于最大充盈压和正常或低动脉压的离体心脏中。将血液灌注的冠状动脉循环与左心泵出的晶体溶液分离,以便对工作瓣膜进行视频内镜检查。柔性环比刚性环对二尖瓣环的正常运动干扰更小,对心室底部充盈的损害也更小,并且无负荷搏出量要大16%。对于正常动脉压,差异较小,在临床情况下难以检测到。可见在收缩期僵硬的瓣环被推到主动脉瓣下方,这导致轻度瓣下梗阻。刚性瓣环成形环上的平均舒张压梯度略大于相同或略小舒张尺寸的柔性环。刚性环改变了瓣叶的运动模式;壁侧瓣叶在整个舒张期保持不动。虽然杜兰环比卡彭蒂埃环对瓣膜功能和心室底部充盈的干扰更小,但差异很小,可能在临床上只有有限的重要性。