Department of Forest Products Technology, School of Chemical Technology, Aalto University , P.O. Box 16300, 00076 Aalto, Finland.
Biomacromolecules. 2012 Mar 12;13(3):736-42. doi: 10.1021/bm201661k. Epub 2012 Feb 8.
A generic approach for heterogeneous surface modification of cellulosic materials in aqueous medium, applicable for a wide range of functionalizations, is presented. In the first step, carboxymethyl cellulose (CMC) modified with azide or alkyne functionality, was adsorbed on a cellulosic substrate, thus, providing reactive sites for azide-alkyne cycloaddition click reactions. In the second step, functional units with complementary click units were reacted on the cellulose surface, coated by the click-modified CMC. Selected model functionalizations on diverse cellulosic substrates are shown to demonstrate the generality of the approach. The concept by sequentially combining the robust physical adsorption ("physical click") and robust chemical reaction ("chemical click") allows versatile, simple, and environmentally friendly modification of a cellulosic substrate with virtually any azide- or alkyne-modified molecule and even functionalization with several types of units.
本文提出了一种在水相介质中对纤维素材料进行异质表面修饰的通用方法，适用于广泛的功能化。在第一步中，用叠氮化物或炔基官能团修饰的羧甲基纤维素（CMC）被吸附在纤维素基底上，从而为叠氮化物-炔烃环加成点击反应提供了反应位点。在第二步中，带有互补点击单元的功能单元与纤维素表面反应，该表面由点击改性的 CMC 覆盖。在各种纤维素基底上进行的选定模型功能化，证明了该方法的通用性。通过顺序结合稳健的物理吸附（“物理点击”）和稳健的化学反应（“化学点击”）的概念，可以实现对纤维素基底的多功能、简单和环保的修饰，几乎可以用任何带有叠氮化物或炔基修饰的分子进行修饰，甚至可以用几种类型的单元进行功能化。
