Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, 25, Rue du Dr. Roux, 75724 Paris Cedex 15, France.
Emerg Infect Dis. 2012 Jan;18(1):86-90. doi: 10.3201/eid1801.110556.
We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.
我们报告了 20 例由获得性棘白菌素耐药的念珠菌属引起的感染，这些念珠菌属携带不同的新型 Fksp 突变。对于 12 名患者，初始分离株（低 MIC，野生型 Fksp 序列）和后续分离株（在卡泊芬净治疗后，高 MIC，突变的 Fksp）在遗传上相关。
