Szarvas Judit, Rebelo Ana Rita, Bortolaia Valeria, Leekitcharoenphon Pimlapas, Schrøder Hansen Dennis, Nielsen Hans Linde, Nørskov-Lauritsen Niels, Kemp Michael, Røder Bent Løwe, Frimodt-Møller Niels, Søndergaard Turid Snekloth, Coia John Eugenio, Østergaard Claus, Westh Henrik, Aarestrup Frank Møller
Division for Global Surveillance, National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Department of Clinical Microbiology, Herlev Hospital, 2730 Herlev, Denmark.
J Fungi (Basel). 2021 Nov 12;7(11):962. doi: 10.3390/jof7110962.
and are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the population in the country. The majority of the 30 isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight isolates were predicted to be prevalent subtypes. Antifungal susceptibility testing proved all isolates to be susceptible to both azoles and echinocandins. Two isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species.
[具体真菌名称1]和[具体真菌名称2]是机会性真菌病原体，在全球范围内发病率不断上升，在丹麦的患病率高于预期。我们对从丹麦临床微生物实验室收集的酵母分离株进行了全基因组测序，以了解该国[具体真菌名称1]的种群概况。在30株[具体真菌名称1]分离株中，大多数属于三个全球流行的进化枝，除了一株外，其余分离株预计也会与其他地理位置的样本聚类。同样，8株[具体真菌名称2]分离株中的大多数预计为流行亚型。抗真菌药敏试验证明，所有[具体真菌名称1]分离株对唑类和棘白菌素均敏感。两株[具体真菌名称1]分离株表现出唑类耐药表型，但对棘白菌素均敏感。两种真菌的种群结构和耐药表型之间均无因果关系迹象。
